HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178503698, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Reactant | HCID 178503699 | HCID 178503699 | — |
| Product | HCID 178503698 | HCID 178503698 | 81% |
Reaction Steps
Prepared analogously to Example 17 from N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methylsulfanylpropyl]-3-chloro-4-[(2S)-2-(N-tert-butoxycarbonylaminomethyl)pyrrolidin-1-ylcarbonyl]benzamide and trifluoroacetic acid. Yield: 81%; Rf value: 0.18 (silica gel; dichloromethane/methanol/ammonia=9:1:0.1); C24H27Cl2N5O2S (520.48); mass spectrum: (M+H)-=520/522/524 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-15b6a4f45d0e4382a1ef3982632973de |
| Source note | uspto-grants-2008_02 |