Methanol → HCID 178427160, compound

Participants

Reaction Steps

0.3 g (0.49 mmol) of N-[(1S)-5-(benzyloxycarbonylamino)-1-(5-chloro-1H-benzimidazol-2-yl)pentyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide is dissolved in 15 mL of dichloromethane and, after the addition of 0.25 mL (0.76 mmol) of iodotrimethylsilane, stirred for 3 hours at ambient temperature. Then 10 mL of methanol is added and the mixture is stirred for a further 30 minutes. The solvent is distilled off and the residue is chromatographed on silica gel, eluting with dichloromethane/methanol (80:20). Yield: 0.22 g (96%); Rf value: 0.15 (silica gel; dichloromethane/methanol=9:1); C25H30ClN5O2 (468.00); mass spectrum: (M+H)+=468/470 (chlorine isotope).

Provenance & Evidence