HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → HCID 178474743, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | HCID 178427160 | HCID 178427160 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178474743 | HCID 178474743 | 55% |
Reaction Steps
Prepared analogously to Example 23a from N-[(1S)-5-amino-1-(5-chloro-1H-benzimidazol-2-yl)pentyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide, acetyl chloride, and triethylamine in tetrahydrofuran. Yield: 55%; Rf value: 0.2 (silica gel; dichloromethane/methanol=9:1); C27H32ClN5O3 (510.04); mass spectrum: (M−H)−=510/512 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-73321c7a0fa94f32a2965de1994ad0bf |
| Source note | uspto-grants-2008_02 |