HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178427103, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Methyl 4-(pyrrolidin-1-ylcarbonyl)benzoic acid | HCID 12068686 | — |
| Reactant | HCID 178453674 | HCID 178453674 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | HCID 21585052 | HCID 21585052 | — |
| Product | HCID 178427103 | HCID 178427103 | 64% |
Reaction Steps
Prepared analogously to Example 1g from 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and 2-tert-butoxycarbonylamino-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine in tetrahydrofuran. Yield: 64%; Rf value: 0.67 (silica gel; cyclohexane/ethanol=7:3); C27H32ClN5O4 (526.03); mass spectrum: (M+H)+=526/528 (chlorine isotope) and (M−H)−=524/526 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-9325eb540cb24375bf01f6e71602d5af |
| Source note | uspto-grants-2008_02 |