HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → HCID 178474874, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | HCID 178427101 | HCID 178427101 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178474874 | HCID 178474874 | 62% |
Reaction Steps
Prepared analogously to Example 124 from N-[2-amino-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide, acetic anhydride, and triethylamine in tetrahydrofuran. Yield: 62%; Rf value: 0.16 (silica gel; dichloromethane/methanol=19:1); C24H26ClN5O3 (467.95); mass spectrum: (M+H)+=468/470 (chlorine isotope) and (M−H)-=466/468 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-562377abfa8d4262b98f871d1c32bf34 |
| Source note | uspto-grants-2008_02 |