HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl chloride → HCID 178427102, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | HCID 178427101 | HCID 178427101 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178427102 | HCID 178427102 | 65% |
Reaction Steps
Prepared analogously to Example 125 from N-[2-amino-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide, benzoyl chloride, and triethylamine in tetrahydrofuran. Yield: 65%; Rf value: 0.32 (silica gel; dichloromethane/methanol=19:1); C29H28ClN5O3 (530.03); mass spectrum: (M+H)+=530/532 (chlorine isotope) and (M−H)-=528/530 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-425bb6ea2ce14a3b946cb5276b548d6c |
| Source note | uspto-grants-2008_02 |