HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178427081, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Methyl 4-(pyrrolidin-1-ylcarbonyl)benzoic acid | HCID 12068686 | — |
| Reactant | HCID 178511063 | HCID 178511063 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Ethyl acetate acetate | HCID 22609514 | — |
| Product | HCID 178427081 | HCID 178427081 | 53% |
Reaction Steps
Prepared analogously to Example 1g from 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, 3-benzyloxycarbonyl-1-(5-chloro-1H-benzimidazol-2-yl)propylamine in dimethylsulfoxide and sodium hydroxide solution. Yield: 53%; Rf value: 0.16 (silica gel; ethyl acetate/acetic acid=95:5); C24H25ClN4O4 (468.94); mass spectrum: (M+H)+=469/471 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-8e8c707abdee4180bc6dd7101a713de5 |
| Source note | uspto-grants-2008_02 |