HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178427181, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | HCID 69309945 | HCID 69309945 | — |
| Solvent | HCID 21925750 | HCID 21925750 | — |
| Product | HCID 178427181 | HCID 178427181 | 68% |
Reaction Steps
Prepared analogously to Example 17 from N-[(1S)-1-(1-tert-butoxycarbonyl-5-chlorobenzimidazol-2-yl)-3-hydroxycarbonylpropyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide and trifluoroacetic acid. Yield: 68%; Rf value: 0.50 (silica gel; ethyl acetate/ethanol/acetic acid=85:15:5); C24H25ClN4O4 (468.94); mass spectrum: (M+H)+=469/471 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-74b9d9283ff0465eb1d252e1049ba6ef |
| Source note | uspto-grants-2008_02 |