HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178427082, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Methyl 4-(pyrrolidin-1-ylcarbonyl)benzoic acid | HCID 12068686 | — |
| Reactant | HCID 178511063 | HCID 178511063 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | HCID 178427082 | HCID 178427082 | 70% |
Reaction Steps
Prepared analogously to Example 1g from 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and 3-benzyloxycarbonyl-1-(5-chloro-1H-benzimidazol-2-yl)propylamine in tetrahydrofuran. Yield: 70%; Rf value: 0.24 (silica gel; ethyl acetate/ethanol=95:5); C31H31ClN4O4 (559.06); mass spectrum: (M+H)+=559/561 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-a18d1770b5e2467487d35be97ccb00b0 |
| Source note | uspto-grants-2008_02 |