HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylamine → HCID 178465112, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178427081 | HCID 178427081 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | HCID 178465112 | HCID 178465112 | 67% |
Reaction Steps
Prepared analogously to Example 1g from rac.-N-[1-(5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonylpropyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide, TBTU, diisopropylethylamine, and ethylamine in tetrahydrofuran. Yield: 67%; Rf value: 0.24 (silica gel; ethyl acetate/ethanol=95:5); C26H30ClN5O3 (496.01); mass spectrum: (M+H)+=496/498 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-b98b5702f00f4ea1baacf31d8d0ac995 |
| Source note | uspto-grants-2008_02 |