HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178427202, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Methyl 4-(pyrrolidin-1-ylcarbonyl)benzoic acid | HCID 12068686 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178427202 | HCID 178427202 | 43% |
Reaction Steps
Prepared analogously to Example 1g from 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and (R)-(5-chloro-1H-benzimidazol-2-yl)-2-hydroxyethylamine in tetrahydrofuran. Yield: 43%; Rf value: 0.28 (silica gel; dichloromethane/methanol/ammonia=9:1:0.1); C22H23ClN4O3 (426.90); mass spectrum: (M+H)+=427/429 (chlorine isotope) and (M−H)−=425/427 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-08ddd225241e4af78fb1a85712df5e11 |
| Source note | uspto-grants-2008_02 |