HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178427168, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | HCID 178427169 | HCID 178427169 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178427168 | HCID 178427168 | 54% |
Reaction Steps
Prepared analogously to Example 17 from (S)—N-[4-(tert-butoxycarbonylamino)-1-(5-chloro-1H-benzimidazol-2-yl)butyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide and trifluoroacetic acid. Yield: 54%; Rf value: 0.21 (silica gel; dichloromethane/methanol=9:1); C24H28ClN5O2 (453.97); mass spectrum: (M+H)+=454/456 (chlorine isotope) and (M−H)-=452/454 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-f1dbbeabe2fc4a06ba1e983100bee602 |
| Source note | uspto-grants-2008_02 |