Acetic Anhydride → HCID 178474862, compound

Participants

Reaction Steps

170 mg (0.4 mmol) of (1S)—N-[2-amino-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide is placed in 3.4 mL of tetrahydrofuran, while being cooled in the ice bath with 0.1 mL (0.6 mmol) of triethylamine and then combined with 0.05 g (0.45 mmol) of acetic anhydride. Then the mixture is heated to ambient temperature and stirred for 24 hours. Then the solvent is eliminated in vacuo and the residue purified by chromatography (gradient: dichloromethane/methanol=100:2). Yield: 23.5 mg (13%); Rf value: 0.28 (silica gel; dichloromethane/methanol=95:5); C24H26ClN5O3 (467.95); mass spectrum: (M+H)+=468/470 (chlorine isotope).

Provenance & Evidence