HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → HCID 178474774, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | HCID 178427168 | HCID 178427168 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178474774 | HCID 178474774 | 73% |
Reaction Steps
Prepared analogously to Example 124 from (1S)—N-[4-amino-1-(5-chloro-1H-benzimidazol-2-yl)butyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide, acetic anhydride, and triethylamine in tetrahydrofuran. Yield: 73%; Rf value: 0.73 (silica gel; dichloromethane/methanol=95:5); C26H30ClN5O3 (496.01); mass spectrum: (M+H)+=496/498 (chlorine isotope) and (M−H)-=494/496 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-50efca5f3fb349bc8c2069078d8c73cf |
| Source note | uspto-grants-2008_02 |