HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178427204, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | HCID 178427205 | HCID 178427205 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178427204 | HCID 178427204 | 90% |
Reaction Steps
Prepared analogously to Example 17 from N-[(1R)-2-(tert-butoxycarbonylmethyloxy)-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide and trifluoroacetic acid. Yield: 90%; Rf value: 0.50 (silica gel; dichloromethane/methanol=4:1); C24H25ClN4O5 (484.94); mass spectrum: (M+H)+=485/487 (chlorine isotope) and (M−H)-=483/485 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-54a6f4d789794a4daad898f9b3bd11cc |
| Source note | uspto-grants-2008_02 |