HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178516784, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178523088 | HCID 178523088 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178516784 | HCID 178516784 | 44% |
Reaction Steps
Prepared analogously to Example 1g from 3-chloro-N-(5-chloro-1H-benzimidazol-2-ylmethyl)-4-carboxybenzamide, TBTU, diisopropylethylamine, and piperazinone in DMF. Yield: 44%; C20H17Cl2N5O3 (446.29); mass spectrum: (M+H)+=446/448/450 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-4543220e00274ab5bce470571eba5539 |
| Source note | uspto-grants-2008_02 |