HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178427192, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | HCID 178427186 | HCID 178427186 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178427192 | HCID 178427192 | 37% |
Reaction Steps
Prepared analogously to Example 125 from N-[(1S)-3-amino-1-(5-chloro-1H-benzimidazol-2-yl)propyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide, methanesulfonic acid chloride, and triethylamine in dichloromethane. Yield: 37%; Rf value: 0.30 (silica gel; dichloromethane/ethanol=9:1); C24H28ClN5O4S (518.04); mass spectrum: (M+H)+=518/520 (chlorine isotope) and (M−H)−=516/518 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-e7ee45e2202b4178933d21489f6aaf0d |
| Source note | uspto-grants-2008_02 |