反应详情

DIPEA (3.11 mL, 18.03 mmol) was added to a solution of 3-{(phenylmethyl)oxy}-5-((1S)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethoxy)benzoic acid (3.00 g, 7.21 mmol), HATU (3.12 g, 8.21 mmol) and 1-isopropyl-1H-pyrazol-3-amine (1.13 g, 9.01 mmol) in DMF (10 mL). The resulting mixture was stirred at ambient temperature for 16 hours. The DMF was removed in vacuo. The solvent was evaporated and the residue was dissolved in 5% w/v citric acid (50 mL) and ethyl acetate (30 mL) and diethyl ether (30 mL) and the organic layer was further washed with sat. aqueous sodium bicarbonate solution (30 mL) and brine (30 mL). The organic layer was separated, then dried (MgSO4), filtered and evaporated. Purification by column chromatography, eluting with 1:4 to 1:3 ethyl acetate:hexanes, afforded the title compound as a colourless oil (2.40 g, 65%).

1. customThe DMF was removed in vacuo
2. customThe solvent was evaporated
3. dissolutionthe residue was dissolved in 5%
4. washthe organic layer was further washed with sat. aqueous sodium bicarbonate solution (30 mL) and brine (30 mL)
5. customThe organic layer was separated
6. dry with materialdried (MgSO4)
7. filtrationfiltered
8. customevaporated
9. customPurification by column chromatography
10. washeluting with 1:4 to 1:3 ethyl acetate