HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178503697, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Chloro-4-(pyrrolidin-1-ylcarbonyl)benzoic acid | HCID 69315144 | — |
| Reactant | (S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methylsulfanylpropylamine | HCID 178503691 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178503697 | HCID 178503697 | 62% |
Reaction Steps
Prepared analogously to Example 1g from 3-chloro-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and (S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-(methyl-sulfanyl)propylamine in tetrahydrofuran. Yield: 62%; Rf value: 0.50 (silica gel; dichloromethane/ethanol=9:1); C23H24Cl2N4O2S (491.44); mass spectrum: (M+H)+=391/393/395 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-afed6041c46642bfab10f8d81d5b844d |
| Source note | uspto-grants-2008_02 |