HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 178504634, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 3-bromo-N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methylsulfanylpropyl]4-(pyrrolidin-1-ylcarbonyl)benzamide | HCID 178503695 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178504634 | HCID 178504634 | 81% |
Reaction Steps
Prepared analogously to Example 85 from 3-bromo-N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methylsulfanylpropyl]-4-(pyrrolidin-1-ylcarbonyl)benzamide, 1 equivalent of 3-chloroperoxybenzoic acid, and glacial acetic acid in dichloromethane. Yield: 81%; Rf value: 0.20 (silica gel; dichloromethane/ethanol=9:1); C23H24BrClN4O3S (551.89); mass spectrum: (M+H)+=551/553/555 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-5eb9fc66bd9140f9ac7b3ca58fa186a7 |
| Source note | uspto-grants-2008_02 |