HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178462075, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | HCID 178462071 | HCID 178462071 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178462075 | HCID 178462075 | 62% |
Reaction Steps
Prepared analogously to Example 125 from 4-((2R)-2-aminomethylpyrrolidin-1-ylcarbonyl)-3-chloro-N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]benzamide, methanesulfonic acid chloride, and triethylamine in tetrahydrofuran. Yield: 62%; Rf value: 0.31 (silica gel; dichloromethane/ethanol=9:1); C23H25Cl2N5O4S (538.45); mass spectrum: (M+H)+=538/549/542 (chlorine isotope) and (M−H)−=536/538/540 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-36062a04fbbf4791a0ddbd99d2ccb154 |
| Source note | uspto-grants-2008_02 |