HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → HCID 178474852, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Dichloromethane ethanol | HCID 21584144 | — |
| Reactant | HCID 178462071 | HCID 178462071 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 178474852 | HCID 178474852 | 78% |
Reaction Steps
Prepared analogously to Example 124 from 4-((2R)-2-aminomethylpyrrolidin-1-ylcarbonyl)-3-chloro-N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]benzamide and acetic anhydride in glacial acetic acid. Yield: 78%; Rf value: 0.30 (silica gel; dichloromethane/ethanol=9:1); C24H25Cl2N5O3 (502.40); mass spectrum: (M+H)+=502/504/506 (chlorine isotope) and (M−H)−=500/502/504 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-68dd0063486846f29d3f3fb5fb7b3d6b |
| Source note | uspto-grants-2008_02 |