Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
BROMINE CHLORIDE (BrCl) → (1R)-3-bromo-N-[1-(5-chloro-1H-benzimidazol-2-yl)-2-hydroxyethyl]-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | BROMINE CHLORIDE (BrCl) | HCID 61697 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | 3-Bromo-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid | HCID 69309865 | — |
| 반응물 | HCID 178511833 | HCID 178511833 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | (1R)-3-bromo-N-[1-(5-chloro-1H-benzimidazol-2-yl)-2-hydroxyethyl]-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzamide | HCID 178523884 | 84% |
반응 단계
Prepared analogously to Example 1g from 3-bromo-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and (1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-hydroxyethylamine in tetrahydrofuran. Yield: 84%; Rf value: 0.40 (silica gel; dichloromethane/methanol=95:5); C21H18BrClN4O3 (489.76); mass spectrum: (M+H)+=489/491/493 (chlorobromine isotope).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07326791B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-47d857ab3938452db1c631c4f293e3be |
| 출처 메모 | uspto-grants-2008_02 |