HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 178495736, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Methyl-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid | HCID 11858638 | — |
| Reactant | HCID 178495727 | HCID 178495727 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178495736 | HCID 178495736 | 74% |
Reaction Steps
Prepared analogously to Example 1g from 3-methyl-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid, TBTU, N-methylmorpholine, and (1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxyethylamine in N,N-dimethylformamide. Yield: 74%; Rf value: 0.38 (silica gel; dichloromethane/methanol=95:5); C23H23ClN4O3 (438.92); mass spectrum: (M+H)+=439/441 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-572c804d24574de1bf8f44a5777a3181 |
| Source note | uspto-grants-2008_02 |