HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 59655047, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Methyl 4-(pyrrolidin-1-ylcarbonyl)benzoic acid | HCID 12068686 | — |
| Reactant | HCID 86620551 | HCID 86620551 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 59655047 | HCID 59655047 | 42% |
Reaction Steps
Prepared analogously to Example 1g from 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and 1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)ethylamine in dimethylformamide. Yield: 42%; Rf value: 0.45 (silica gel; dichloromethane/ethanol=9:1); C21H22ClN5O2 (411.89); mass spectrum: (M+H)+=410/412 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-37e8a3ab45274eee90fed5a99a438d37 |
| Source note | uspto-grants-2008_02 |