HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 178427152, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Methyl 4-(pyrrolidin-1-ylcarbonyl)benzoic acid | HCID 12068686 | — |
| Reactant | HCID 178461864 | HCID 178461864 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178427152 | HCID 178427152 | 87% |
Reaction Steps
Prepared analogously to Example 1g from 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and (1S)-1-(5-nitro-1H-benzimidazol-2-yl)ethylamine in dimethylformamide. Yield: 87%; Rf value: 0.40 (silica gel; dichloromethane/ethanol=9:1); C22H23N5O4 (421.46); mass spectrum: (M+H)+=422 and (M−H)−=420
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-73a3fd3631f8480bb328d8dc65987d45 |
| Source note | uspto-grants-2008_02 |