HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2053923Generated: October 31, 2026
Hydrochloric Acid → 3-Chloro-4-(pyrrolidin-1-ylsulfonyl)benzonitrile
https://huagongshe.com/reaction/2053923
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 2-Chloro-4-cyanobenzene-1-sulfonyl chloride | HCID 2735722 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-Chloro-4-(pyrrolidin-1-ylsulfonyl)benzonitrile | HCID 69312500 | — |
Reaction Steps
900 mg (4 mmol) of 2-chloro-4-cyanobenzenesulfonic acid chloride is dissolved in 3 mL of pyridine and, after the addition of 0.5 mL (5.8 mmol) of pyrrolidine, stirred for one hour at 80° C. Then the mixture is cooled, mixed with ice, and adjusted to pH 5-6 with 1 molar hydrochloric acid. The precipitate formed is suction filtered, washed with water and dried. Yield: 1.1 g (100% of theory); Rf value: 0.20 (silica gel; petroleum ether/ethyl acetate=4:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07326791B2 |
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| Source dataset | uspto-grants-2008_02 |
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| ORD ID | ord-3b00fd508f5847b9828189c119564c17 |
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| Source note | uspto-grants-2008_02 |
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