HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178427188, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Methyl-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid | HCID 11858638 | — |
| Reactant | HCID 178511826 | HCID 178511826 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178427188 | HCID 178427188 | 100% |
Reaction Steps
Prepared analogously to Example 1g from 3-methyl-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine and (1S)-3-(benzyloxycarbonylamino)-1-(5-chloro-1H-benzimidazol-2-yl)propylamine in dimethylformamide. Yield: 100%; Rf value: 0.50 (silica gel; dichloromethane/ethanol=9:1); C31H30ClN5O4 (572.06); mass spectrum: (M+H)+=572/574 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-d00b764e51514e17a661080fe990fc53 |
| Source note | uspto-grants-2008_02 |