HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178427179, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | (3S)-pyrrolidin-3-ol | HCID 2733874 | — |
| Reactant | HCID 69309945 | HCID 69309945 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | HCID 178427179 | HCID 178427179 | 87% |
Reaction Steps
Prepared analogously to Example 1g from (S)—N-[1-(1-tert-butoxycarbonyl-5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonylpropyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide, TBTU, diisopropylethylamine, (S)pyrrolidine-3-ol in acetonitrile, and subsequent reaction with trifluoroacetic acid analogously to Example 17. Yield: 87%; Rf value: 0.18 (silica gel; ethyl acetate/ethanol=85:15); C28H32ClN5O4 (538.05); mass spectrum: (M+H)+=538/540 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-92376e9d4cae4562b6a8ac5192420300 |
| Source note | uspto-grants-2008_02 |