HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178427170, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 2,6-Diazaspiro[3.4]octane, 2-methyl- | HCID 15107450 | — |
| Reactant | HCID 69309776 | HCID 69309776 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | EtOH ethyl acetate triethylamine | HCID 22328969 | — |
| Product | HCID 178427170 | HCID 178427170 | 67% |
Reaction Steps
Prepared analogously to Example 1g from N-[1-(1-tert-butoxycarbonyl-5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonylpropyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide, TBTU, diisopropylethylamine, 2-methyl-2,6-diazaspiro[3.4]octane in acetonitrile, and subsequent reaction with trifluoroacetic acid analogously to Example 17. Yield: 67%; Rf value: 0.05 (silica gel; ethyl acetate/ethanol/triethylamine=70:27:3); C31H37ClN6O3 (577.13); mass spectrum: (M+H)+=577/579 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-e66118029e064cc0a221a5b2f7f0b4e6 |
| Source note | uspto-grants-2008_02 |