HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178427175, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | tert-Butyl {[(2S)-pyrrolidin-2-yl]methyl}carbamate | HCID 22869529 | — |
| Reactant | HCID 69309776 | HCID 69309776 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | HCID 178427175 | HCID 178427175 | 44% |
Reaction Steps
Prepared analogously to Example 1g from N-[1-(1-tert-butoxycarbonyl-5-chloro-1H-benzimidazol-2-yl)-3-hydroxycarbonylpropyl]-3-methyl-4-(pyrrolidin 1-ylcarbonyl)benzamide, TBTU, diisopropylethylamine, (S)-2-tert-butoxycarbonylaminomethylpyrrolidine in acetonitrile, and subsequent reaction with trifluoroacetic acid analogously to Example 17. Yield: 44%; Rf value: 0.59 (silica gel; ethyl acetate/ethanol=7:3); C34H43ClN6O5 (651.20); mass spectrum: (M+H)+=651/653 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-aadc676a3b4a4b25abcb677a5cb50127 |
| Source note | uspto-grants-2008_02 |