HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178464864, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 69312605 | HCID 69312605 | — |
| Reactant | HCID 178510880 | HCID 178510880 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | HCID 178464864 | HCID 178464864 | 65% |
Reaction Steps
Prepared analogously to Example 1g from 4-(4,5,6,7-tetrahydrobenzimidazol-1-yl)-3-trifluoromethylbenzoic acid, TBTU, triethylamine, and (5-chloro-1H-benzimidazol-2-yl)ethylamine in tetrahydrofuran. Yield: 65%; Rf value: 0.30 (silica gel; ethyl acetate/ethanol=4:1); C24H21ClF3N5O (487.91); mass spectrum: (M−H)−=486/488 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-3fafe55775ce49d39259996cdbe37a48 |
| Source note | uspto-grants-2008_02 |