Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 4-Fluoro-3-(trifluoromethyl)benzoic acid | HCID 522268 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 69309751 | HCID 69309751 | — |
Reaction Steps
7.5 g (36 mmol) of 4-fluoro-3-trifluoromethylbenzoic acid is dissolved in 12 mL dimethylsulfoxide and, after the addition of 15 mL (0.24 mol) of hydrazine hydrate (80%), stirred for 5 hours at 100° C. After cooling, it is combined with ice and acidified with glacial acetic acid. The precipitated product is suction filtered and dried. Yield: 5.3 g (66%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07326791B2 |
|---|
| Source dataset | uspto-grants-2008_02 |
|---|
| ORD ID | ord-aaa65e6afa094205919d644300514b23 |
|---|
| Source note | uspto-grants-2008_02 |
|---|
