Acetonitrile → HCID 69312533, compound

Participants

Reaction Steps

3.7 g (12.1 mmol) of 4-(3-formyl-5,6-dihydro-4H-cyclopentapyrazol-1-yl)-3-trifluoromethylbenzonitrile is dissolved in 60 mL acetonitrile and, after the addition of 4.3 g (36.4 mmol) of tert-butylcarbamate, 5.8 mL (36.4 mmol) of triethylsilane, and 1.9 mL (24.2 mmol) of trifluoroacetic acid, stirred for 20 hours at ambient temperature. The reaction solution is taken up in diethyl ether, washed with sodium hydrogen carbonate solution, and the organic phase is dried and concentrated by evaporation. Yield: quantitative.

Provenance & Evidence