HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 178462099, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Reactant | HCID 69312589 | HCID 69312589 | — |
| Reactant | HCID 178510880 | HCID 178510880 | — |
| Solvent | 1-Methylpyrrolidine | HCID 8454 | — |
| Product | HCID 178462099 | HCID 178462099 | 30% |
Reaction Steps
Prepared analogously to Example 1g from 4-[3-(tert-butoxycarbonylamino)methyl-5,6-dihydro-4H-cyclopentapyrazol-1-yl]-3-trifluoromethylbenzoic acid, TBTU, N-methylmorpholine, and 5-chloro-1H-benzimidazol-2-ylethylamine in N-methylpyrrolidine. Yield: 30%; Rf value: 0.65 (silica gel; dichloromethane/methanol/ammonia=9:1:0.1); C29H30ClF3N6O3 (603.04); mass spectrum: (M+H)+=603/605 (chlorine isotope) and (M−H)-=601/603 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-1aae0808a3594f32ae4b142e3cb2195e |
| Source note | uspto-grants-2008_02 |