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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2053966Generated: October 31, 2026

Chlorine → HCID 178449025, compound

https://huagongshe.com/reaction/2053966

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChlorineHCID 24526—
ReactantDiisopropylethylamineHCID 81531—
ReactantRac.-2-(n-butyl-n-ethylaminomethyl)piperidineHCID 24702057—
ReactantHCID 178464831HCID 178464831—
SolventDimethyl SulfoxideHCID 679—
ProductHCID 178449025HCID 178449025—

Reaction Steps

Prepared analogously to Example 1d from rac.-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, rac.-2-(N-butyl-N-ethylaminomethyl)piperidine, PFTU, and diisopropylethylamine in DMSO at ambient temperature. HPLC-MS results: retention time: 4.23 minutes; C29H37Cl2N5O2 (558.55); mass spectrum: (M−H)−=558/560 (chlorine isotope).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07326791B2
Source datasetuspto-grants-2008_02
ORD IDord-b782420675a24899b429873d372fbf07
Source noteuspto-grants-2008_02