Sodium Hydroxide → 4-(Imidazol-1-ylmethyl)-3-methoxybenzoic acid

HRID 2053998Notes

Reaction equation

HRID 2053998 reaction equation
[N:1]1([CH2:6][C:7]2[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=[O:12])=[CH:9][C:8]=2[O:17][CH3:18])[CH:5]=[CH:4][N:3]=[CH:2]1.[OH-].[Na+]>CO>[N:1]1([CH2:6][C:7]2[CH:16]=[CH:15][C:10]([C:11]([OH:13])=[O:12])=[CH:9][C:8]=2[O:17][CH3:18])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69314851Methyl 4-(imidazol-1-ylmethyl)-3-methoxybenzoate

Product 1

HCID 693124874-(Imidazol-1-ylmethyl)-3-methoxybenzoic acidYield 85%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared analogously to Example 19b from methyl 4-(imidazol-1-ylmethyl)-3-methoxybenzoate and sodium hydroxide solution in methanol. Yield: 85%; C12H12N2O3 (232.24); mass spectrum: (M+H)+=233.

Sources & evidence

ORD record
ord-e72a5d8576234ea2b102c70cad0d55f6
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

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