HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178492723, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | (S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine | HCID 42034613 | — |
| Reactant | HCID 69312522 | HCID 69312522 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178492723 | HCID 178492723 | 59% |
Reaction Steps
Prepared analogously to Example 1g from 3-methoxy-4-(2-oxopyrrolidin-1-ylmethyl)benzoic acid, TBTU, diisopropylethylamine and (1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine in tetrahydrofuran. Yield: 59%; Rf value: 0.41 (silica gel; dichloromethane/ethanol=9:1); C22H23ClN4O3 (426.9); mass spectrum: (M+H)+=427/429 (chlorine isotope) and (M−H)-=425/427 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-1a3c604514a44cc7ace01f361eb964a2 |
| Source note | uspto-grants-2008_02 |