HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178495739, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178495741 | HCID 178495741 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178495739 | HCID 178495739 | 11% |
Reaction Steps
Prepared analogously to Example 1g from 4-{N-[(1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-methoxyethyl]aminocarbonyl}-2-trifluoromethylbenzoic acid, TBTU, diisopropylethylamine and pyrrolidine in tetrahydrofuran. Yield: 11%; Rf value: 0.72 (silica gel: dichloromethane/methanol=9:1); C23H22ClF3N4O3 (494.899); mass spectrum: (M+H)+=495/497 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-1cbd4dcda09744c385aa8d2cd606bfcd |
| Source note | uspto-grants-2008_02 |