HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178459926, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Chloro-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid | HCID 69315164 | — |
| Reactant | HCID 178459925 | HCID 178459925 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178459926 | HCID 178459926 | 40% |
Reaction Steps
Prepared analogously to Example 1g from 3-chloro-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine and (R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-isopropoxycarbonyloxyethylamine in tetrahydrofuran. Yield: 40%; C25H24Cl2N4O5 (531.394); mass spectrum: (M+H)+=531/533/535 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-261bbff0e92b431f9103467708ebf30a |
| Source note | uspto-grants-2008_02 |