HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178471812, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | ethyl 2-[(2S)-pyrrolidin-2-yl]acetate | HCID 51413840 | — |
| Reactant | (1S)-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid | HCID 178462084 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178471812 | HCID 178471812 | 64% |
Reaction Steps
Prepared analogously to Example 1g from (1S)-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, TBTU, diisopropylethylamine, and (S)-2-(ethoxycarbonylmethyl)pyrrolidine in tetrahydrofuran. Yield: 64%; Rf value: 0.42 (silica gel: dichloromethane/ethanol=9:1); C25H26C12N4O4 (517.728); mass spectrum: (M−H)-=515/517/519 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-713aca0ef91348cdad8445c811049d6b |
| Source note | uspto-grants-2008_02 |