HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 178462067, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | HCID 178471812 | HCID 178471812 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178462067 | HCID 178462067 | 63% |
Reaction Steps
Prepared analogously to Example 19b from 3-chloro-N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]-4-[(2S)-2-(ethoxycarbonylmethyl)pyrrolidin-1-ylcarbonyl]benzamide and lithium hydroxide in tetrahydrofuran. Yield: 63%; Rf value: 0.32 (Reversed phase RP 8: methanol/5% sodium chloride solution=6:4); C23H22Cl2N4O4 (489.357); mass spectrum: (M−H)-=487/489/451 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-15fb415bf08e49fc86841014a5f6faed |
| Source note | uspto-grants-2008_02 |