HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178427191, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | HCID 178427185 | HCID 178427185 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178427191 | HCID 178427191 | 58% |
Reaction Steps
Prepared analogously to Example 125 from N-[(1S)-3-amino-1-(5-chloro-1H-benzimidazol-2-yl)propyl]-4-(2,5-dihydropyrrol-1-ylcarbonyl)-3-methylbenzamide, methanesulfonic acid chloride and triethylamine in tetrahydrofuran. Yield: 58%; Rf value: 0.40 (silica gel: dichloromethane/ethanol=9:1); C24H26ClN5O4 (516.019); mass spectrum: (M+H)+=516/518 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-9f422f1231fb4bed9e71750dfd8344dc |
| Source note | uspto-grants-2008_02 |