HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylpyrrolidine → HCID 178426209, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylpyrrolidine | HCID 13003 | — |
| Reactant | BROMINE CHLORIDE (BrCl) | HCID 61697 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178462082 | HCID 178462082 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178426209 | HCID 178426209 | 22% |
Reaction Steps
Prepared analogously to Example 1g from (1S)-2-bromo-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, TBTU, diisopropylethylamine and rac.-2-methylpyrrolidine in dimethylformamide. Yield: 22%; Rf value: 0.45 (silica gel: dichloromethane/ethanol=9:1); C22H22BrClN4O2 (489.799); mass spectrum: (M+H)+=489/491/493 (bromo-chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-2aa6a8b0c81345ee93a196737d354933 |
| Source note | uspto-grants-2008_02 |