HuagongsheHuagongshe Chemistry Print Report · For research reference only
BROMINE CHLORIDE (BrCl) → HCID 178462081, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | BROMINE CHLORIDE (BrCl) | HCID 61697 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 45092297 | HCID 45092297 | — |
| Reactant | HCID 178462082 | HCID 178462082 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178462081 | HCID 178462081 | 23% |
Reaction Steps
Prepared analogously to Example 1g from (1S)-2-bromo-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, TBTU, diisopropylethylamine and rac.-2-(tert-butoxycarbonylaminomethyl)thiazolidine in dimethylformamide. Yield: 23%; Rf value: 0.52 (silica gel: dichloromethane/methanol/glacial acetic acid=9:1:0.1); C26H29BrClN5O4S (622.969); mass spectrum: (M−H)−=620/622/624 (bromo-chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-40e705a8fa204585b387b6c99e99841d |
| Source note | uspto-grants-2008_02 |