HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178427143, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | (S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine | HCID 42034613 | — |
| Reactant | HCID 69309871 | HCID 69309871 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178427143 | HCID 178427143 | 49% |
Reaction Steps
Prepared analogously to Example 1g from rac.-4-(3-fluoropyrrolidin-1-ylcarbonyl)-3-methylbenzoic acid, TBTU, diisopropylethylamine and (1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine in tetrahydrofuran. Yield: 49%; Rf value: 0.30 (silica gel: dichloromethane/ethanol=9:1); C22H22ClFN4O2 (428.893); mass spectrum: (M+H)+=429/431 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-0d08152f6ab94078bc5db616f8b4666b |
| Source note | uspto-grants-2008_02 |