HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178471813, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | (R)-Ethyl 2-(pyrrolidin-2-yl)acetate | HCID 12333240 | — |
| Reactant | (1S)-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid | HCID 178462084 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178471813 | HCID 178471813 | 59% |
Reaction Steps
Prepared analogously to Example 1g from (1S)-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, TBTU, diisopropylethylamine, and (2R)-2-(ethoxy-carbonylmethyl)pyrrolidine in tetrahydrofuran. Yield: 59%; Rf value: 0.42 (silica gel: dichloromethane/ethanol=9:1); C25H26Cl2N4O4 (517.271); mass spectrum: (M+H)+=517/519/521 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-996a1960d76047069c795841d34bbe12 |
| Source note | uspto-grants-2008_02 |