HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178474226, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | Dichloromethane ethanol | HCID 21584144 | — |
| Reactant | 4-(N-acetyl-N-cyclopentylamino)-3-methylbenzoic acid | HCID 69309740 | — |
| Reactant | (S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methylsulfanylpropylamine | HCID 178503691 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178474226 | HCID 178474226 | 9% |
Reaction Steps
Prepared analogously to Example 1g from 4-(N-acetyl-N-cyclopentylamino)-3-methylbenzoic acid, TBTU, diisopropylethylamine, and (1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methylsulfanylpropylamine in tetrahydrofuran. Yield: 9%; Rf value: 0.68 (silica gel: dichloromethane/ethanol=9:1); C26H31ClN4O2S (499.076); mass spectrum: (M+H)+=499/501 (chlorine isotope) and (M−H)−=497/499 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-efe966ea45b0419fa8eb577d7fdff2c3 |
| Source note | uspto-grants-2008_02 |