HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178462057, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | 3-Pyrroline | HCID 66059 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178462083 | HCID 178462083 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178462057 | HCID 178462057 | 55% |
Reaction Steps
Prepared analogously to Example 1g from (1S)-2-trifluoromethyl-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, TBTU, diisopropylethylamine, and 3-pyrroline in tetrahydrofuran. Yield: 55%; Rf value: 0.50 (silica gel: dichloromethane/ethanol=9:1); C22H18ClF3N4O2 (462.863); mass spectrum: (M+H)+=463/465 (chlorine isotope) and (M−H)−=461/463 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-458a1cd7529242729487be661d284219 |
| Source note | uspto-grants-2008_02 |