HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178462070, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 1-{[(2R)-pyrrolidin-2-yl]methyl}-1H-imidazole | HCID 28063973 | — |
| Reactant | (1S)-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid | HCID 178462084 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178462070 | HCID 178462070 | 50% |
Reaction Steps
Prepared analogously to Example 1g from 2-chloro-4-{N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, TBTU, diisopropylethylamine, and (R)-1-(pyrrolidin-2-ylmethyl)-1H-imidazole in tetrahydrofuran. Yield: 50%; Rf value: 0.20 (silica gel: dichloromethane/methanol=9:1); C25H24C12N6O2 (511.415); mass spectrum: (M+H)+=511/513/515 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-3845681bdf9446b2bcd3a5312255d18c |
| Source note | uspto-grants-2008_02 |